Endocrine Abstracts

A 22-year-old Caucasian female was referred to thyroid specialist clinic due to difficulties fully suppressing her thyroid stimulating hormone (TSH) despite high dose combination therapy of triiodothyronine (T3) and thyroxine (T4) treatment. She had a well-differentiated thyroid -carcinoma of left thyroid lobe treated with left lobectomy. Several other small primary thyroid carcinoma lesions were detected on further examination of the histology which lead to completion thyroid...

Management of newly-diagnosed non-functioning pituitary adenomas (NFPAs) has evolved over the last decade. Whilst surgical debulking remains the mainstay of treatment for patients presenting with compressive disease, the use of pituitary irradiation has declined, with greater emphasis on observation or further surgical debulking. We aimed to compare outcomes of treatment for NFPAs at our institution since 2004 with older management strategies.We reviewed...

In vivo the 11β-HSD1 enzyme converts inactive cortisone to the active glucocorticoid cortisol. 11β-HSD1 is implicated in the metabolic syndrome through its expression in liver and adipose tissue by increasing local cortisol concentrations. However, little is known regarding the expression and function of 11β-HSD1 in muscle.Murine C2C12 muscle cells (myocytes) were differentiated from myoblasts to myotubules for 8 days, with and without the...

Introduction: Bilateral adrenalectomy (BADx) is a treatment option in ACTH-dependent Cushing’s syndrome refractory to other therapeutic modalities or can be an emergency measure in cases with severe manifestations of hypercortisolaemia.Aim: To review the outcomes of our patients with ACTH-dependent Cushing’s offered BADx.Methods: Records of patients with ACTH-dependent Cushing’s managed by BADx and seen in our Depart...

Introduction: Cabergoline is one of the medical treatments in acromegaly; it can be used alone or in combination with other available agents.Aim: To review the efficacy of cabergoline in patients with acromegaly treated in our centre.Patients and methods: Patients with acromegaly on cabergoline were identified from our Pituitary Registry. Clinical/laboratory/imaging data were collected and analysed.Results: F...

Introduction: Silent somatotroph Pituitary Neuroendocrine Tumours (PitNETs) are extremely rare (2−3% of surgically treated pituitary tumours) and data on their natural history and outcomes are scarce.Aim: To review systematically the cases of these tumours presenting in our Centre.Patients and methods: Patients with this diagnosis were identified from our Pituitary Registry and clinical/laboratory/imaging data were collected ...

Introduction: Functioning gonadotroph adenomas (FGAs) are very rare tumours secreting biologically active gonadotropins. In males, typically, FSH levels are elevated, whereas LH and testosterone are variable. Herein, we present three males with elevated, normal or low testosterone at diagnosis.Cases: Case 1:42-year-old man with two-year history of visual impairment. Bitemporal hemianopia was confirmed. Imaging showed macroadenoma compressing optic chiasm...